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Title: Antimicrobial Activity of Essential Oils and Solvent Extracts from 'Zieria' species (Rutaceae)
Contributor(s): Sadgrove, Nicholas (author); Jones, Graham L (author)orcid 
Publication Date: 2013
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Abstract: Essential oils were hydrodistilled from six 'Zieria' species, including two previously not investigated: 'Z. floydii' and 'Z. odorifera' subsp. 'williamsii', and characterized using GC-MS. Additionally, solvent extracts of leaf material from five of these species were prepared using n-hexane, acetone and methanol as solvents, respectively. These solvent extracts were examined, along with essential oils, for antibacterial activity using micro titer plate broth dilution assays. Antifungal activity against pathogenic 'Trichophyton' species responsible for dermal infections such as Tinea and Kangaroo Pox (uncommon), was examined using a similar method. Results of essential oil characterizations are relatively consistent with those previously reported. Interestingly, the essential oil composition of 'Z. floydii' showed car-3-en-2-one at a concentration of 71%, similar to that observed in a previous study for 'Z. furfuracea' and 'Z. granulata', thus complementing the observations of A.G. Floyd that 'Z. floydii' is morphologically allied with these two species (CANB 598758). Antimicrobial assays demonstrated relatively high antibacterial and antifungal activity, using both essential oils and solvent extracts. This is particularly true for the n-hexane extract from 'Z. smithii'. We therefore conclude that 'Zieria' species may be a useful source for the development of antiseptic, cosmaceutical and/or topical nutraceutical products. In addition, they may well serve as a source of further novel, purified compounds providing scaffolds for pharmaceutical development in the future.
Publication Type: Journal Article
Source of Publication: Natural Product Communications, 8(6), p. 741-745
Publisher: Natural Product Inc
Place of Publication: United States of America
ISSN: 1555-9475
Field of Research (FOR): 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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