Gondro, Cedric

Kwan, Paul H

2012

Chapter reprinted in Information Resources Management Association. (2013). <em>Bioinformatics: Concepts, Methodologies, Tools, and Applications</em>. Volume 1. Medical Information Science Reference, p. 105-129

Evolutionary Computation (EC) is a branch of Artificial Intelligence which encompasses heuristic optimization methods loosely based on biological evolutionary processes. These methods are efficient in finding optimal or near-optimal solutions in large, complex non-linear search spaces. While evolutionary algorithms (EAs) are comparatively slow in comparison to deterministic or sampling approaches, they are also inherently parallelizable. As technology shifts towards multi core and cloud computing, this overhead becomes less relevant, provided a parallel framework is used. In this chapter the authors discuss how to implement and run parallel evolutionary algorithms in the popular statistical programming language R. R has become the de facto language for statistical programming and it is widely used in bio statistics and bio informatics due to the availability of thousands of packages to manipulate and analyze data. It is also extremely easy to parallelize routines within R, which makes it a perfect environment for evolutionary algorithms. EC' is a large field of research, and many different algorithms have been proposed. While there is no single silver bullet that can handle all classes of problems, an algorithm that is extremely simple, efficient, and with good generalization properties is Differential Evolution (DE). Herein the authors discuss step-by-step how to implement DE in R and how to parallelize it. They then illustrate with a to y genome-wide association study (GWAS) how to indent candidate regions associated with a quantitative trait of interest.

Multidisciplinary Computational Intelligence Techniques: Applications in Business, Engineering, and Medicine, p. 351-377

9781466618305

9781466618312

9781466618329

https://hdl.handle.net/1959.11/12392

en

Information Science Reference

1

Parallel Evolutionary Computation in R

Book Chapter

Publication