Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12347
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Seung Hwanen
dc.contributor.authorVan Der Werf, Julius Hen
dc.contributor.authorThompson, John Men
dc.contributor.authorLee, Sang Hongen
dc.contributor.authorLim, Da Jeongen
dc.contributor.authorPark, Eung Wooen
dc.contributor.authorGondro, Cedricen
dc.contributor.authorYoon, Duhaken
dc.contributor.authorOh, Sung Jongen
dc.contributor.authorKim, Oun Hyunen
dc.contributor.authorGibson, Johnen
dc.date.accessioned2013-03-28T12:55:00Z-
dc.date.issued2012-
dc.identifier.citationGenes and Genomics, 34(1), p. 43-49en
dc.identifier.issn2092-9293en
dc.identifier.issn1976-9571en
dc.identifier.urihttps://hdl.handle.net/1959.11/12347-
dc.description.abstractMeat quality traits are the most economically important traits affecting the beef industry in Korea. We performed a whole genome quantitative trait locus (QTL) mapping study of carcass data in Hanwoo Korean cattle. Two hundred sixty-six Hanwoo steers from 65 sires were genotyped using a 10K Affymetrix SNP chip. The average SNP interval across the bovine genome was 1.5Mb. Associations between each individual SNP and four carcass traits [carcass weight (CWT), eye muscle area (EMA), back fat thickness (BFT), and marbling (MAR)] were assessed using a linear mixed model of each trait. Combined linkage and linkage disequilibrium analysis (LDLA) detected six potential QTL on BTA04, 06, 13, 16, 17, and 23 at the chromosome-wise level (P<0.05). Two MAR QTL were detected at 52.2 cM of BTA06 and 46.04 cM of BTA17. We identified three genes (ARAP2, LOC539460, and LOC511424) in the QTL region of BTA06 and seven genes (RPS14, SCARB1, LOC782103, BRI3BP, AACS, DHX37, and UBC) in the QTL region of BTA17. One significant QTL for CWT was detected at 100 cM on BTA04 and the corresponding QTL region spanned 1.7 cM from 99.7 to 101.4 cM. For EMA QTL, one significant QTL was detected at 3.9 cM of BTA23 and the most likely QTL interval was 1.4 cM, placing 15 candidate genes in the marker bracket. Finally, two QTL for BFT were identified at 68 cM on BTA13 and 24 cM on BTA16. The LPIN3 gene, which is functionally associated with lipodystrophy in humans, is located in the BFT QTL on BTA13. Thus, two potential candidate genes, acetoacetyl-CoA synthetase (AACS) and lipin (LPIN), were detected in QTL regions on BTA17 for MAR and BTA13 for BFT, respectively. In conclusion, LDLA analysis can be used to detect chromosome regions harboring QTL and candidate genes with a low density SNP panel, yielding relatively narrow confidence intervals regarding location.en
dc.languageenen
dc.publisherGenetics Society of Koreaen
dc.relation.ispartofGenes and Genomicsen
dc.titleGenome wide QTL mapping to identify candidate genes for carcass traits in Hanwoo (Korean cattle)en
dc.typeJournal Articleen
dc.identifier.doi10.1007/s13258-011-0081-6en
dc.subject.keywordsQuantitative Genetics (incl Disease and Trait Mapping Genetics)en
local.contributor.firstnameSeung Hwanen
local.contributor.firstnameJulius Hen
local.contributor.firstnameJohn Men
local.contributor.firstnameSang Hongen
local.contributor.firstnameDa Jeongen
local.contributor.firstnameEung Wooen
local.contributor.firstnameCedricen
local.contributor.firstnameDuhaken
local.contributor.firstnameSung Jongen
local.contributor.firstnameOun Hyunen
local.contributor.firstnameJohnen
local.subject.for2008060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)en
local.subject.seo2008830301 Beef Cattleen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjvanderw@une.edu.auen
local.profile.emailjthompso@une.edu.auen
local.profile.emailslee46@korea.kren
local.profile.emailcgondro2@une.edu.auen
local.profile.emailjgibson5@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20130323-181015en
local.publisher.placeRepublic of Koreaen
local.format.startpage43en
local.format.endpage49en
local.identifier.scopusid84862787793en
local.peerreviewedYesen
local.identifier.volume34en
local.identifier.issue1en
local.contributor.lastnameLeeen
local.contributor.lastnameVan Der Werfen
local.contributor.lastnameThompsonen
local.contributor.lastnameLeeen
local.contributor.lastnameLimen
local.contributor.lastnameParken
local.contributor.lastnameGondroen
local.contributor.lastnameYoonen
local.contributor.lastnameOhen
local.contributor.lastnameKimen
local.contributor.lastnameGibsonen
dc.identifier.staffune-id:slee52en
dc.identifier.staffune-id:jvanderwen
dc.identifier.staffune-id:jthompsoen
dc.identifier.staffune-id:cgondro2en
dc.identifier.staffune-id:jgibson5en
local.profile.orcid0000-0003-2512-1696en
local.profile.orcid0000-0003-0666-656Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:12554en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleGenome wide QTL mapping to identify candidate genes for carcass traits in Hanwoo (Korean cattle)en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorLee, Seung Hwanen
local.search.authorVan Der Werf, Julius Hen
local.search.authorThompson, John Men
local.search.authorLee, Sang Hongen
local.search.authorLim, Da Jeongen
local.search.authorPark, Eung Wooen
local.search.authorGondro, Cedricen
local.search.authorYoon, Duhaken
local.search.authorOh, Sung Jongen
local.search.authorKim, Oun Hyunen
local.search.authorGibson, Johnen
local.uneassociationUnknownen
local.identifier.wosid000303589300007en
local.year.published2012en
local.subject.for2020310506 Gene mappingen
local.subject.seo2020100401 Beef cattleen
Appears in Collections:Journal Article
School of Environmental and Rural Science
Files in This Item:
2 files
File Description SizeFormat 
Show simple item record

SCOPUSTM   
Citations

14
checked on Jun 29, 2024

Page view(s)

1,458
checked on Jul 7, 2024

Download(s)

2
checked on Jul 7, 2024
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.