Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12302
Title: Selection of pigs for improved coping with health and environmental challenges: breeding for resistance or tolerance?
Contributor(s): Guy, Sarita  (author)orcid ; Thomson, Peter C (author); Hermesch, Susanne  (author)orcid 
Publication Date: 2012
Open Access: Yes
DOI: 10.3389/fgene.2012.00281Open Access Link
Handle Link: https://hdl.handle.net/1959.11/12302
Abstract: The benefits of improved health and welfare in pigs have driven refinements in management and selection practices, one of which is the production of pig phenotypes that can maintain health and productivity by improving response against pathogens. Selection has traditionally been made for host resistance; but the alternative host defence mechanism - host tolerance - is now being considered, as breeding for disease tolerance allows maintenance of high performance across environments of increasing pathogenic load. A distinction must be made between these two mechanisms as they vary in their influence on host-pathogen interactions and pathogen evolution, and consequently on the results of breeding programs. Many pig production studies have failed to distinguish between resistance and tolerance; although a distinction may not always be possible. This article reviews current perspectives in selective breeding for disease resistance and tolerance in growing pigs, and the attendant industry implications. To assess the viability of breeding for resistance and/or tolerance for improved response to disease and other environmental challenges, we propose the use of routine farm records, instead of data measurements taken from laboratory experiments. Consequently, a number of factors need to be taken into account simultaneously for a multidimensional modeling approach. This includes not only genotype and disease variables, but also descriptors of the environment, as well as any possible interactions. It may not be feasible to record individual pathogen loads, and therefore true tolerance, on farm using routinely collected data. However, it may be estimated with group (farm) means, or other proxy measures. Although this results in a bias, this may still be useful for modeling and quantifying resistance and tolerance. We can then quantify success of selection, and this may enable us to decide whether to select for disease resistance versus disease tolerance.
Publication Type: Journal Article
Source of Publication: Frontiers in Genetics, v.3, p. 1-9
Publisher: Frontiers Research Foundation
Place of Publication: Switzerland
ISSN: 1664-8021
Field of Research (FOR): 070201 Animal Breeding
Socio-Economic Outcome Codes: 830308 Pigs
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article

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