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Title: Pooling Estimates of Covariance Components Using a Penalized Maximum Likelihood Approach
Contributor(s): Meyer, Karin  (author)
Publication Date: 2012
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Abstract: Estimates of large genetic covariance matrices are commonly obtained by pooling results from a series of analyses of small subsets of traits. Procedures available to pool the part-estimates differ in their efficacy in accounting for unequal accuracies of estimates and sampling correlations, and ensuring that pooled matrices are within the parameter space. We propose a maximum likelihood (ML) approach to combine estimates, treating sets from individual part-analyses as matrices of mean squares and cross-products from independent families. This facilitates simultaneous pooling of estimates for all sources of variation considered, readily allows for weighted estimation or a given structure of the pooled matrices, and provides a framework for regularized estimation by penalizing the likelihood. A simulation study is presented, comparing the quality of combined estimates for several procedures, including truncation or shrinkage of either canonical or individual matrix eigen-values, iterative summation of expanded part matrices, and the ML approach, considering a range of penalties. Shrinking eigen-values of individual matrices towards their mean reduced losses in the pooled estimates, but substantially increased proportional losses in their phenotypic counterparts and thus yielded estimates differing most from corresponding full multivariate analyses of all traits. Assuming a simple pseudo-pedigree structure when combining estimates for all random effects simultaneously using ML allowed sampling correlations between estimates of different components from the same part-analysis to be approximated sufficiently to yield pooled matrices closest to full multivariate results, with little change in phenotypic components. Imposing a mild penalty to shrink matrices for random effects towards their sum proved highly advantageous, markedly reducing losses in estimates and more than compensating for the reduction in efficiency of using the data inherent in analyses by parts. Penalized ML provides a flexible alternative to current methods for pooling estimates from part-analyses with good sampling properties, and should be adopted more widely.
Publication Type: Conference Publication
Conference Name: ICQG 2012: Fourth International Conference of Quantitative Genetics - Understanding Variation in Complex Traits, Edinburgh, Scotland, 17th - 22nd June, 2012
Conference Details: ICQG 2012: Fourth International Conference of Quantitative Genetics - Understanding Variation in Complex Traits, Edinburgh, Scotland, 17th - 22nd June, 2012
Source of Publication: 4th International Conference on Quantitative Genetics: Understanding Variation in Complex Traits Programme & Book of Abstracts, p. 68-68
Publisher: In Conference Ltd
Place of Publication: online
Field of Research (FOR): 010405 Statistical Theory
070201 Animal Breeding
060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
Socio-Economic Outcome Codes: 830399 Livestock Raising not elsewhere classified
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
HERDC Category Description: E3 Extract of Scholarly Conference Publication
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Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
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