Please use this identifier to cite or link to this item:
Title: Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure
Contributor(s): Smart, Neil  (author)orcid ; Meyer, Tim (author); Giallauria, Francesco  (author); Butterfield, John (author); Faddy, SC (author); Passino, C (author); Malfatto, G (author); Jonsdottir, S (author); Sarullo, F (author); Wisloff, U (author); Vigorito, C (author)
Publication Date: 2012
DOI: 10.1177/1741826711409171
Handle Link:
Abstract: Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP. Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO₂; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO₂. Design: Individual patient meta-analysis. Methods: A systematic search was conducted of Medline (Ovid),, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO₂. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures. Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p<0.0001), NT-pro-BNP (-37.4%, p=<0.0001), and peak VO₂ (17.8%, p<0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r= -0.31, p<0.0001) and NT-pro-BNP (r= -0.22, p<0.0001) were correlated with peak VO₂ change. Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO₂ in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO₂ changes.
Publication Type: Journal Article
Source of Publication: European Journal of Preventive Cardiology, 19(3), p. 428-435
Publisher: Sage Publications Ltd
Place of Publication: United Kingdom
ISSN: 2047-4873
Field of Research (FOR): 110201 Cardiology (incl Cardiovascular Diseases)
110602 Exercise Physiology
Socio-Economic Outcome Codes: 920103 Cardiovascular System and Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 286
Views: 396
Downloads: 0
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record


checked on Nov 30, 2018

Page view(s)

checked on Mar 2, 2019
Google Media

Google ScholarTM



Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.