Smart, Neil; Meyer, Tim; Giallauria, Francesco; Butterfield, John; Faddy, SC; Passino, C; Malfatto, G; Jonsdottir, S; Sarullo, F; Wisloff, U; Vigorito, C

Author(s)

Smart, Neil

Meyer, Tim

Giallauria, Francesco

Butterfield, John

Faddy, SC

Passino, C

Malfatto, G

Jonsdottir, S

Sarullo, F

Wisloff, U

Vigorito, C

Publication Date

2012

Abstract

Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP. Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO₂; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO₂. Design: Individual patient meta-analysis. Methods: A systematic search was conducted of Medline (Ovid), Embase.com, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO₂. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures. Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p<0.0001), NT-pro-BNP (-37.4%, p=<0.0001), and peak VO₂ (17.8%, p<0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r= -0.31, p<0.0001) and NT-pro-BNP (r= -0.22, p<0.0001) were correlated with peak VO₂ change. Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO₂ in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO₂ changes.

Citation

European Journal of Preventive Cardiology, 19(3), p. 428-435

ISSN

2047-4881

2047-4873

Link

https://hdl.handle.net/1959.11/12016

Publisher

Sage Publications Ltd

Title

Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure

Type of document

Journal Article

Entity Type

Publication

Author(s)	Smart, Neil Meyer, Tim Giallauria, Francesco Butterfield, John Faddy, SC Passino, C Malfatto, G Jonsdottir, S Sarullo, F Wisloff, U Vigorito, C
Publication Date	2012
Abstract	Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP. Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO₂; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO₂. Design: Individual patient meta-analysis. Methods: A systematic search was conducted of Medline (Ovid), Embase.com, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO₂. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures. Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p<0.0001), NT-pro-BNP (-37.4%, p=<0.0001), and peak VO₂ (17.8%, p<0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r= -0.31, p<0.0001) and NT-pro-BNP (r= -0.22, p<0.0001) were correlated with peak VO₂ change. Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO₂ in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO₂ changes.
Citation	European Journal of Preventive Cardiology, 19(3), p. 428-435
ISSN	2047-4881 2047-4873
Link	https://hdl.handle.net/1959.11/12016
Publisher	Sage Publications Ltd
Title	Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure
Type of document	Journal Article
Entity Type	Publication

Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure

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