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|Title:||Fenbendazole as a possible marker of supplement intake in sheep||Contributor(s):||Fishpool, Fiona Joy (author); Kahn, Lewis (author) ; Tucker, David (author); Nolan, John V (author) ; Leng, Ronald (author)||Publication Date:||2011||Handle Link:||https://hdl.handle.net/1959.11/10850||Abstract:||This study aimed to determine the dose-dependent relationship between oral doses of fenbendazole (FBZ) and the plasma concentration of its metabolites, oxfendazole (OFZ) and fenbendazole-sulphone (SUL). Twenty five, two year-old, Merino wethers were equally allocated to treatment groups of different oral dose rates of FBZ (n = 5) and housed in individual pens. Treatment groups were designed to provide daily oral doses of 0.25, 0.5, 1.0, 2.0 and 4.0 mg/kg live weight of FBZ, suspended in water, for six days. Blood samples were collected from each animal at 48, 96, and 144 hours after administration of FBZ. Plasma was equally combined within each animal and analysed to determine concentrations of FBZ, OFZ and SUL. There was a positive linear relationship between FBZ dose rate and FBZ metabolite plasma concentration (R² = 0.991, P <0.001). Mean separation of plasma concentrations indicated significant differences (P <0.05) between treatments designed to provide 1.0, 2.0 or 4.0 mg/kg/day FBZ. Plasma concentrations of animals which received 0.25 or 0.50 mg/kg/day FBZ were significantly lower than other treatments (P <0.05). The results from this experiment provide preliminary support for the investigation of FBZ as a useful marker to estimate supplement intake of grazing animals.||Publication Type:||Conference Publication||Conference Name:||71st Annual New Zealand Society of Animal Production (NZSAP) Conference, Invercargill, New Zealand, 29th June - 1st July, 2011||Source of Publication:||Proceedings of the New Zealand Society of Animal Production, p. 13-16||Publisher:||New Zealand Society of Animal Production||Place of Publication:||New Zealand||ISSN:||0370-2731||Field of Research (FOR):||070203 Animal Management||Peer Reviewed:||Yes||HERDC Category Description:||E1 Refereed Scholarly Conference Publication||Other Links:||http://www.nzsap.org.nz/proc/2011/ab11004.html||Series Name:||New Zealand Society of Animal Production Proceedings||Series Number :||71||Statistics to Oct 2018:||Visitors: 181
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School of Environmental and Rural Science
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