Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/10780
Title: | Modulation of Growth Hormone-Releasing Factor Stimulated Growth Hormone Secretion by Plasma Glucose and Free Fatty Acid Concentrations in Sheep | Contributor(s): | Sartin, JL (author); Bartol, FF (author); Kemppainen, RJ (author); Dieberg, Gudrun (author) ; Buxton, D (author); Soyoola, E (author) | Publication Date: | 1988 | DOI: | 10.1159/000125073 | Handle Link: | https://hdl.handle.net/1959.11/10780 | Abstract: | Effects of plasma glucose and free fatty acid (FFA) concentrations on bovine growth hormone-releasing factor (bGRF)-induced release of growth hormone (GH) were examined in ovariohysterectomized sheep. In experiment 1, the effects of an infusion of insulin (0.025 U/kg BW·h⁻¹), glucose (40 mg/kg BW·h⁻¹), insulin plus glucose or saline on the subsequent effects of bGRF on plasma GH concentrations were determined. Insulin-induced hypoglycemia inhibited GRF effects on plasma GH concentrations while glucose infusion enhanced bGRF actions. Infusing a higher glucose dose (120 mg/kg BW·h⁻¹) had no effect on GRF actions. Subsequently, infusion of FFA (0.25 g/kg/·h⁻¹), nicotinic acid (50 mg/kg BW) or saline for 1 h prior to bGRF injection demonstrated that FFA inhibited GRF actions but FFA depletion by nicotinic acid infusion had no effect on GRF actions. Nicotinic acid (40 mg/kg BW·h⁻¹) infused for 2 h prior to bGRF injection significantly enhanced bGRF-stimulated GH secretion. Finally, to determine whether central nervous system glucopenia produced similar effects to insulin-induced hypoglycemia, 2-deoxyglucose (500 mg) was injected into the lateral ventricle followed in 1 h by the i.v. injection of bGRF. The central glucopenia produced by 2-DG inhibited GRF-stimulated GH release. These data demonstrate that decreased peripheral or central nervous system glucose availability and exogenous administration of FFA antagonized GRF-induced release of GH. And, pharmacologic depletion of circulating FFA for at least 2 h facilitated GRF-induced release of GH. | Publication Type: | Journal Article | Source of Publication: | Neuroendocrinology, 48(6), p. 627-633 | Publisher: | S Karger AG | Place of Publication: | Switzerland | ISSN: | 1423-0194 0028-3835 |
Fields of Research (FoR) 2008: | 060603 Animal Physiology - Systems | Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
44
checked on Nov 25, 2023
Page view(s)
1,124
checked on Jul 23, 2023
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.