Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/10579
Title: | Regulation of metabolism and growth during prenatal life | Contributor(s): | Bell, A W (author); Greenwood, Paul (author); Ehrhardt, R A (author) | Publication Date: | 2005 | DOI: | 10.1016/S1877-1823(09)70008-6 | Handle Link: | https://hdl.handle.net/1959.11/10579 | Abstract: | Fetal energy and nitrogen requirements are met mostly by placental transfer of glucose and amino acids; fatty acids may contribute additional energy in some species. Placental metabolism accounts for much of the total net consumption of oxygen and macronutrients by the conceptus, and alters the composition of nutrients delivered to the fetus. The molecular basis for the facilitated transport of glucose by the placenta is well described; molecular characterization of the more complex systems for the active transport of most amino acids is under way. Maternal and placental macronutrient supply is a powerful regulator of fetal metabolism and growth, especially in late gestation. Endocrine mediation of these responses matures as gestation advances, adding to the influences of locally expressed regulators throughout gestation. Insulin, thyroid hormones, and, near term, corticosteroids, are especially influential in the direct and indirect control of fetal nutrient disposal and tissue growth. Prenatal growth retardation does not necessarily constrain the rate of neonatal growth, but at any given postnatal body weight, low-birth-weight lambs are fatter and have smaller muscles. Experimental evidence is accumulating for longer-term influences of prenatal nutrition through fetal programming of propensity for mature-onset diseases such as hypertension and type II diabetes. | Publication Type: | Book Chapter | Source of Publication: | Biology of Metabolism in Growing Animals, p. 3-34 | Publisher: | Elsevier BV | Place of Publication: | Amsterdam, Netherlands | ISBN: | 9780444510136 0444510133 |
Fields of Research (FoR) 2008: | 070206 Animal Reproduction 070204 Animal Nutrition 070202 Animal Growth and Development |
Socio-Economic Objective (SEO) 2008: | 830399 Livestock Raising not elsewhere classified | HERDC Category Description: | B1 Chapter in a Scholarly Book | Publisher/associated links: | http://trove.nla.gov.au/work/13000601 | Series Name: | Biology of Growing Animals | Series Number : | 3 | Editor: | Editor(s): Douglas Burrin and Harry Mersmann |
---|---|
Appears in Collections: | Book Chapter |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
24
checked on Mar 16, 2024
Page view(s)
928
checked on Mar 9, 2023
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.