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Title: Effects of acute insulin deficiency on catecholamine and indoleamine content and catecholamine turnover in microdissected hypothalamic nuclei in streptozotocin-diabetic rats
Contributor(s): Oliver, EH (author); Sartin, JL (author); Dieberg, Gudrun  (author)orcid ; Rahe, CH (author); Marple, DN (author); Kemppainen, RJ (author)
Publication Date: 1989
DOI: 10.1530/acta.0.1200343
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Abstract: The effects of streptozotocin-induced diabetes on catecholamine and indoleamine concentrations and catecholamine turnover rates in individual microdissected hypothalamic nuclei known, or believed, to be involved in the control of neuroendocrine function, were examined in control, insulin-treated diabetic and acutely insulin-withdrawn diabetic female rats. Streptozotocin-induced diabetes and acute insulin deficiency were demonstrated to result in increased concentrations of epinephrine in the suprachiasmatic nucleus, decreased turnover of epinephrine in the arcuate nucleus and decreased turnover of dopamine in the ventromedial nucleus was found to be increased in the insulin-treated diabetic animals. These data indicate that experimental diabetes and acute insulin deficiency result in the rapid onset of detectable alterations in epinephrine and dopamine activity in specific hypothalamic nuclei. These diabetes-induced changes may cause, or contribute to, the development of secondary neuroendocrine abnormalities known to occur in the diabetic condition.
Publication Type: Journal Article
Source of Publication: Acta Endocrinologica, 120(3), p. 343-350
Publisher: Editura Academiei Romane
Place of Publication: Norway
ISSN: 0001-5598
Field of Research (FOR): 060603 Animal Physiology - Systems
Socio-Economic Outcome Codes: 920106 Endocrine Organs and Diseases (excl. Diabetes)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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