Effects of acute insulin deficiency on catecholamine and indoleamine content and catecholamine turnover in microdissected hypothalamic nuclei in streptozotocin-diabetic rats

Title
Effects of acute insulin deficiency on catecholamine and indoleamine content and catecholamine turnover in microdissected hypothalamic nuclei in streptozotocin-diabetic rats
Publication Date
1989
Author(s)
Oliver, EH
Sartin, JL
Dieberg, Gudrun
( author )
OrcID: https://orcid.org/0000-0001-7191-182X
Email: gdieberg@une.edu.au
UNE Id une-id:gdieberg
Rahe, CH
Marple, DN
Kemppainen, RJ
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
European Society of Endocrinology
Place of publication
Norway
DOI
10.1530/acta.0.1200343
UNE publication id
une:10766
Abstract
The effects of streptozotocin-induced diabetes on catecholamine and indoleamine concentrations and catecholamine turnover rates in individual microdissected hypothalamic nuclei known, or believed, to be involved in the control of neuroendocrine function, were examined in control, insulin-treated diabetic and acutely insulin-withdrawn diabetic female rats. Streptozotocin-induced diabetes and acute insulin deficiency were demonstrated to result in increased concentrations of epinephrine in the suprachiasmatic nucleus, decreased turnover of epinephrine in the arcuate nucleus and decreased turnover of dopamine in the ventromedial nucleus was found to be increased in the insulin-treated diabetic animals. These data indicate that experimental diabetes and acute insulin deficiency result in the rapid onset of detectable alterations in epinephrine and dopamine activity in specific hypothalamic nuclei. These diabetes-induced changes may cause, or contribute to, the development of secondary neuroendocrine abnormalities known to occur in the diabetic condition.
Link
Citation
Acta Endocrinologica, 120(3), p. 343-350
ISSN
0001-5598
Start page
343
End page
350

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