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Title: Action of the Crustacean Hyperglycemic Hormone (CHH) on Adenylate Cyclase and Phosphodiesterase in Crayfish Abdominal Muscle
Contributor(s): Sedlmeier, D (author); Dieberg, Gudrun (author)orcid 
Publication Date: 1982
DOI: 10.1016/0016-6480(82)90008-9
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Abstract: Investigations on the mode of action of the crustacean hyperglycemic hormone (CHH) revealed an increase of CAMP and cGMP concentrations in the abdominal muscle after the application of this hormone, indicating a second messenger mechanism comparable to the mechanism already known for vertebrate peptide hormones. A maximal stimulation of CAMP was shown 10 min after the injection of the hormone, whereas in cGMP, a constant increase up to 20 min was demonstrated. It should be expected that this elevation is due to an activation of adenylate and guanylate cyclase, but we cannot rule out the possibility of an inhibition of the phosphodiesterases caused by the hormone, which would also result in an increase of the cyclic nucleotides. The time course of the adenylate cyclase activity after hormone injection shows a pattern similar to the one we know for the CAMP concentrations. As one should expect, there is a little time delay between the action of the adenylate cyclase and the increase of CAMP. CAMP phosphodiesterase shows changes in activity comparable to CAMP increase. This increase obviously is due to the elevated CAMP concentrations and not to an immediate action of the hormone on phosphodiesterase. cGMP phosphodiesterase follows more or less the same pattern, an observation which coincides with the cGMP elevation curve. Guanylate cyclase was not measured. From these results, it seems clear that the increase in cyclic nucleotides after hormone injection is due to the action of cyclases and not to an inhibition of phosphodiesterases.
Publication Type: Conference Publication
Conference Name: 11th European Society for Comparative Endocrinology Conference of Comparative Endocrinologists (CECE), Jerusalem, Isreal, 10th - 14th August, 1981
Conference Details: 11th European Society for Comparative Endocrinology Conference of Comparative Endocrinologists (CECE), Jerusalem, Isreal, 10th - 14th August, 1981
Source of Publication: Abstracts of Papers Read at the Eleventh Conference of European Comparative Endocrinologists: August 10-14, 1981 Jerusalem, Israel, p. 384-385
Publisher: Academic Press
Place of Publication: United States of America
ISSN: 0016-6480
Field of Research (FOR): 060107 Enzymes
HERDC Category Description: E3 Extract of Scholarly Conference Publication
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Series Name: General and Comparative Endocrinology
Series Number : vol. 46, no. 3
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