Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/10129
Title: Modelling Marek's Disease Virus (MDV) infection: parameter estimates for mortality rate and infectiousness
Contributor(s): Atkins, Katherine E (author); Read, Andrew F (author); Savill, Nicholas J (author); Renz, Katrin  (author); Walkden-Brown, Steve W  (author)orcid ; Woolhouse, Mark E J (author)
Publication Date: 2011
Open Access: Yes
DOI: 10.1186/1746-6148-7-70Open Access Link
Handle Link: https://hdl.handle.net/1959.11/10129
Abstract: Background: Marek's disease virus (MDV) is an economically important oncogenic herpesvirus of poultry. Since the 1960s, increasingly virulent strains have caused continued poultry industry production losses worldwide. To understand the mechanisms of this virulence evolution and to evaluate the epidemiological consequences of putative control strategies, it is imperative to understand how virulence is defined and how this correlates with host mortality and infectiousness during MDV infection. We present a mathematical approach to quantify key epidemiological parameters. Host lifespan, virus latent periods and host viral shedding rates were estimated for unvaccinated and vaccinated birds, infected with one of three MDV strains. The strains had previously been pathotyped to assign virulence scores according to pathogenicity of strains in hosts. Results: Our analyses show that strains of higher virulence have a higher viral shedding rate, and more rapidly kill hosts. Vaccination enhances host life expectancy but does not significantly reduce the shedding rate of the virus. While the primary latent period of the virus does not vary with challenge strain nor vaccine treatment of host, the time until the maximum viral shedding rate is increased with vaccination. Conclusions: Our approach provides the tools necessary for a formal analysis of the evolution of virulence in MDV, and potentially simpler and cheaper approaches to comparing the virulence of MDV strains.
Publication Type: Journal Article
Source of Publication: BMC Veterinary Research, 7(November), p. 1-12
Publisher: BioMed Central Ltd
Place of Publication: London, United Kingdom
ISSN: 1746-6148
Field of Research (FOR): 070712 Veterinary Virology
070205 Animal Protection (Pests and Pathogens)
Socio-Economic Outcome Codes: 830309 Poultry
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 219
Views: 222
Downloads: 1
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

14
checked on Nov 30, 2018

Page view(s)

104
checked on Feb 18, 2019
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.