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|Title:||QTL and gene expression analyses identify genes affecting carcass weight and marbling on BTA14 in Hanwoo (Korean Cattle)||Contributor(s):||Lee, Seung Hwan (author); Van Der Werf, Julius H (author) ; Kim, Nam Kuk (author); Lee, Sanghong (author); Gondro, Cedric (author) ; Park, Eung Woo (author); Oh, Sung Jong (author); Gibson, John P (author); Thompson, John M (author)||Publication Date:||2011||DOI:||10.1007/s00335-011-9331-9||Handle Link:||https://hdl.handle.net/1959.11/10127||Abstract:||Causal mutations affecting quantitative trait variation can be good targets for marker-assisted selection for carcass traits in beef cattle. In this study, linkage and linkage disequilibrium analysis (LDLA) for four carcass traits was undertaken using 19 markers on bovine chromosome 14. The LDLA analysis detected quantitative trait loci (QTL) for carcass weight (CWT) and eye muscle area (EMA) at the same position at around 50 cM and surrounded by the markers FABP4SNP2774C>G and FABP4_μsat3237. The QTL for marbling (MAR) was identified at the midpoint of markers BMS4513 and RM137 in a 3.5-cM marker interval. The most likely position for a second QTL for CWT was found at the midpoint of tenth marker bracket (FABP4SNP2774C>G and FABP4_μsat3237). For this marker bracket, the total number of haplotypes was 34 with a most common frequency of 0.118. Effects of haplotypes on CWT varied from a -5-kg deviation for haplotype 6 to +8 kg for haplotype 23. To determine which genes contribute to the QTL effect, gene expression analysis was performed in muscle for a wide range of phenotypes. The results demonstrate that two genes, LOC781182 (p = 0.002) and TRPS1 (p = 0.006) were upregulated with increasing CWT and EMA, whereas only LOC614744 (p = 0.04) has a significant effect on intramuscular fat (IMF) content. Two genetic markers detected in FABP4 were the most likely QTL position in this QTL study, but FABP4 did not show a significant effect on both traits (CWT and EMA) in gene expression analysis. We conclude that three genes could be potential causal genes affecting carcass traits CWT, EMA, and IMF in Hanwoo.||Publication Type:||Journal Article||Source of Publication:||Mammalian Genome, 22(9-10), p. 589-601||Publisher:||Springer New York LLC||Place of Publication:||New York, United States of America||ISSN:||1432-1777
|Field of Research (FOR):||070201 Animal Breeding||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 424
|Appears in Collections:||Journal Article|
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