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https://hdl.handle.net/1959.11/10123
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DC Field | Value | Language |
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dc.contributor.author | Kelly, Gareth A | en |
dc.contributor.author | Walkden-Brown, Steve W | en |
dc.contributor.author | Kahn, Lewis | en |
dc.date.accessioned | 2012-05-09T11:31:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Veterinary Parasitology, 183(3-4), p. 274-283 | en |
dc.identifier.issn | 1873-2550 | en |
dc.identifier.issn | 0304-4017 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/10123 | - |
dc.description.abstract | This study aimed to quantify production loss due to larval challenge in sheep administered a controlled release albendazole capsule (CRC) and thus determine the suitability of CRC treated sheep as a proxy for worm-free sheep in grazing experiments. The experiment used an incomplete 2 x 3 latin square design with 81 Merino wethers. Sheep were either infected (INF) with mixed oral infection of albendazole-susceptible 'Haemonchus contortus', 'Trichostrongylus colubriformis', and 'Teladorsagia circumcincta' (initial bolus then thrice weekly maintenance) or remained uninfected (UINF). Worm control treatments were with a CRC (CRCT), threshold treatment with a short-acting anthelmintic when worm egg count (WEC) exceeded 1500 epg (TT) or untreated (UT). The experiment was conducted in two 63-day periods (separated by a 14 day washout period) with infection treatments swapped between periods. A subset of animals was killed at the end of each period for worm counts and tissue sampling. Faecal worm egg count in UINF-UT reached 10,204 and 6078 epg at day 63 in periods 1 and 2, respectively, and remained 0 throughout in the CRT treatments. There was no difference in live weight gain or wool growth of INF-CRCT sheep (67 and 70 g/d) relative to UINF-CRCT (67 and 76 g/d). Live weight gain was significantly lower in INF-UT (27 g/d) and INF-TT (55 g/d) than UINF-UT (88 g/d) or UINF-TT (81 g/d) treatments. During the first infection period, greasy fleece weight growth was significantly lower in INF-UT (6.33 g/d) and INF-TT (6.37 g/d) than UINF-UT (7.80 g/d) or UINF-TT (7.32 g/d) treatments. The effects of infection on production persisted in INF-UT, but not INF-TT sheep for several weeks after termination of infection. Eosinophil counts were elevated in all infected groups and the antibody response to 'T. colubriformis' was greater in INF-CRCT and INF-TT groups compared to uninfected sheep. Together, these results indicate that larval challenge in sheep with a CRC is mildly immunogenic but is not associated with production loss. The results also showed that the CRC itself reduced live weight gain and that anthelmintic treatment at a WEC threshold of 1500 epg reduces production loss during infections and prevents persistence of adverse effects following infection. | en |
dc.language | en | en |
dc.publisher | Elsevier BV | en |
dc.relation.ispartof | Veterinary Parasitology | en |
dc.title | No loss of production due to larval challenge in sheep given continuous anthelmintic treatment via a controlled release capsule | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1016/j.vetpar.2011.07.033 | en |
dc.subject.keywords | Animal Protection (Pests and Pathogens) | en |
dc.subject.keywords | Veterinary Parasitology | en |
local.contributor.firstname | Gareth A | en |
local.contributor.firstname | Steve W | en |
local.contributor.firstname | Lewis | en |
local.subject.for2008 | 070708 Veterinary Parasitology | en |
local.subject.for2008 | 070205 Animal Protection (Pests and Pathogens) | en |
local.subject.seo2008 | 830311 Sheep - Wool | en |
local.subject.seo2008 | 830310 Sheep - Meat | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | Office of Faculty of Science, Ag, Business and Law | en |
local.profile.email | gkelly4@une.edu.au | en |
local.profile.email | swalkden@une.edu.au | en |
local.profile.email | lkahn3@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20120428-140756 | en |
local.publisher.place | Netherlands | en |
local.format.startpage | 274 | en |
local.format.endpage | 283 | en |
local.identifier.scopusid | 83255176903 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 183 | en |
local.identifier.issue | 3-4 | en |
local.contributor.lastname | Kelly | en |
local.contributor.lastname | Walkden-Brown | en |
local.contributor.lastname | Kahn | en |
dc.identifier.staff | une-id:gkelly4 | en |
dc.identifier.staff | une-id:swalkden | en |
dc.identifier.staff | une-id:lkahn3 | en |
local.profile.orcid | 0000-0002-0638-5533 | en |
local.profile.orcid | 0000-0002-3679-4530 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:10316 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | No loss of production due to larval challenge in sheep given continuous anthelmintic treatment via a controlled release capsule | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Kelly, Gareth A | en |
local.search.author | Walkden-Brown, Steve W | en |
local.search.author | Kahn, Lewis | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000299458100011 | en |
local.year.published | 2012 | en |
local.subject.for2020 | 300909 Veterinary parasitology | en |
local.subject.for2020 | 300304 Animal protection (incl. pests and pathogens) | en |
local.subject.seo2020 | 100413 Sheep for wool | en |
local.subject.seo2020 | 100412 Sheep for meat | en |
Appears in Collections: | Journal Article School of Environmental and Rural Science |
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