Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/10123
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dc.contributor.authorKelly, Gareth Aen
dc.contributor.authorWalkden-Brown, Steve Wen
dc.contributor.authorKahn, Lewisen
dc.date.accessioned2012-05-09T11:31:00Z
dc.date.issued2012en
dc.identifier.citationVeterinary Parasitology, 183(3-4), p. 274-283en
dc.identifier.issn1873-2550en
dc.identifier.issn0304-4017en
dc.identifier.urihttps://hdl.handle.net/1959.11/10123en
dc.description.abstractThis study aimed to quantify production loss due to larval challenge in sheep administered a controlled release albendazole capsule (CRC) and thus determine the suitability of CRC treated sheep as a proxy for worm-free sheep in grazing experiments. The experiment used an incomplete 2 x 3 latin square design with 81 Merino wethers. Sheep were either infected (INF) with mixed oral infection of albendazole-susceptible 'Haemonchus contortus', 'Trichostrongylus colubriformis', and 'Teladorsagia circumcincta' (initial bolus then thrice weekly maintenance) or remained uninfected (UINF). Worm control treatments were with a CRC (CRCT), threshold treatment with a short-acting anthelmintic when worm egg count (WEC) exceeded 1500 epg (TT) or untreated (UT). The experiment was conducted in two 63-day periods (separated by a 14 day washout period) with infection treatments swapped between periods. A subset of animals was killed at the end of each period for worm counts and tissue sampling. Faecal worm egg count in UINF-UT reached 10,204 and 6078 epg at day 63 in periods 1 and 2, respectively, and remained 0 throughout in the CRT treatments. There was no difference in live weight gain or wool growth of INF-CRCT sheep (67 and 70 g/d) relative to UINF-CRCT (67 and 76 g/d). Live weight gain was significantly lower in INF-UT (27 g/d) and INF-TT (55 g/d) than UINF-UT (88 g/d) or UINF-TT (81 g/d) treatments. During the first infection period, greasy fleece weight growth was significantly lower in INF-UT (6.33 g/d) and INF-TT (6.37 g/d) than UINF-UT (7.80 g/d) or UINF-TT (7.32 g/d) treatments. The effects of infection on production persisted in INF-UT, but not INF-TT sheep for several weeks after termination of infection. Eosinophil counts were elevated in all infected groups and the antibody response to 'T. colubriformis' was greater in INF-CRCT and INF-TT groups compared to uninfected sheep. Together, these results indicate that larval challenge in sheep with a CRC is mildly immunogenic but is not associated with production loss. The results also showed that the CRC itself reduced live weight gain and that anthelmintic treatment at a WEC threshold of 1500 epg reduces production loss during infections and prevents persistence of adverse effects following infection.en
dc.languageenen
dc.publisherElsevier BVen
dc.relation.ispartofVeterinary Parasitologyen
dc.titleNo loss of production due to larval challenge in sheep given continuous anthelmintic treatment via a controlled release capsuleen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.vetpar.2011.07.033en
dc.subject.keywordsAnimal Protection (Pests and Pathogens)en
dc.subject.keywordsVeterinary Parasitologyen
local.contributor.firstnameGareth Aen
local.contributor.firstnameSteve Wen
local.contributor.firstnameLewisen
local.subject.for2008070708 Veterinary Parasitologyen
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.seo2008830311 Sheep - Woolen
local.subject.seo2008830310 Sheep - Meaten
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolOffice of Faculty of Science, Ag, Business and Lawen
local.profile.emailgkelly4@une.edu.auen
local.profile.emailswalkden@une.edu.auen
local.profile.emaillkahn3@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20120428-140756en
local.publisher.placeAmsterdam, The Netherlandsen
local.format.startpage274en
local.format.endpage283en
local.peerreviewedYesen
local.identifier.volume183en
local.identifier.issue3-4en
local.contributor.lastnameKellyen
local.contributor.lastnameWalkden-Brownen
local.contributor.lastnameKahnen
dc.identifier.staffune-id:gkelly4en
dc.identifier.staffune-id:swalkdenen
dc.identifier.staffune-id:lkahn3en
local.profile.orcid0000-0002-0638-5533en
local.profile.orcid0000-0002-3679-4530en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:10316en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleNo loss of production due to larval challenge in sheep given continuous anthelmintic treatment via a controlled release capsuleen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 248<br />Views: 263<br />Downloads: 0en
local.search.authorKelly, Gareth Aen
local.search.authorWalkden-Brown, Steve Wen
local.search.authorKahn, Lewisen
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School of Environmental and Rural Science
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