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https://hdl.handle.net/1959.11/10119
Title: | Effects of echinacea supplementation on alkylamide pharmacokinetics | Contributor(s): | Agnew, Linda (author) ; Addison, Russel S (author); Matthias, Anita (author); Bone, Kerry (author); Lehmann, Reg (author); Watson, Kenneth (author) | Publication Date: | 2010 | DOI: | 10.1055/s-0030-1264915 | Handle Link: | https://hdl.handle.net/1959.11/10119 | Abstract: | Echinacea preparations are widely used for the prevention and treatment of colds and flu. Studies have shown that alkylamides are present in plasma after oral dosing with echinacea preparations [1,2]. It is well known that continued use of certain drugs can result in changes to their clearance rate and hence their pharmacokinetic profiles and therapeutic effects. Pharmacokinetic data such as this does not exist for the prophylactic use of echinacea. In this study, the effects of supplementation with echinacea on alkylamide bioavailability and pharmacokinetics were examined before and after prophylactic use of echinacea. Six healthy volunteers aged 24 to 66 years with a body mass index ranging from 22.7 to 24.6 participated in the study. They consumed 2 echinacea tablets twice a day for 14 days. On days 0 and 15, participants consumed 4 echinacea tablets (a total of 17.67mg of alkylamides). Blood samples were taken at 0, 30, 90, 120, 180, 240 and 360 minutes post dose and alkylamide levels were determined as previously described [1]. There was no evidence for either the induction or inhibition of alkylamide metabolism as evidenced by consistent elimination half life data. There was a trend towards more rapid alkylamide absorption and achievement of a higher Cmax before the prophylactic use of echinacea but these changes were not statistically significant and there was no difference to the extent of absorption (AUC). Plasma ratios of the tetraene alkylamides were also examined. These were similar to those found in the tablets used in the study and were not altered after prophylactic use of echinacea. In conclusion, prophylactic use of echinacea for 2 weeks does not appear to alter the pharmacokinetics of the alkylamides in echinacea. | Publication Type: | Conference Publication | Conference Details: | GA 2010: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September, 2010 | Source of Publication: | Planta Medica: Journal of Medicinal Plant and Natural Product Research, v.76, p. 1351-1351 | Publisher: | Georg Thieme Verlag | Place of Publication: | Germany | ISSN: | 1439-0221 0032-0943 |
Fields of Research (FoR) 2008: | 110704 Cellular Immunology 110399 Clinical Sciences not elsewhere classified 110499 Complementary and Alternative Medicine not elsewhere classified |
Socio-Economic Objective (SEO) 2008: | 920412 Preventive Medicine 920108 Immune System and Allergy |
HERDC Category Description: | E3 Extract of Scholarly Conference Publication | Series Name: | Planta Medica | Series Number : | 76 |
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Appears in Collections: | Conference Publication |
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