Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/10118
Title: Echinacea induced hsp70 alterations in leukocytes
Contributor(s): Agnew, Linda  (author)orcid ; Matthias, Anita (author); Shipp, Christopher (author); Kauter, Kathleen (author); Bone, Kerry (author); Watson, Kenneth  (author); Lehmann, Reg (author)
Publication Date: 2010
DOI: 10.1055/s-0030-1264927
Handle Link: https://hdl.handle.net/1959.11/10118
Abstract: Heat shock proteins (hsp) are expressed constitutively as well as induced in response to mild stress. These stress factors include inflammation, viral and bacterial infection, oxidative stress and cytotoxins. Altered hsp expression has been found in a number of disease states [1]. Echinacea is used as a prophylactic to boost the immune system and has been previously shown to enhance hsp70 expression in leucocytes after mild heat shock [2]. In this study, the effects of echinacea supplementation on hsp70 expression in the different leucocyte subpopulations has been examined. Twenty four healthy volunteers aged between 20 and 66 years with a body mass index ranging from 20.2 to 30.7 participated in the study. They consumed 2 echinacea tablets (4.42mg total alkylamides per tablet) twice a day for 14 days. Blood samples were taken on days 1 and 15 and hsp70 expression was determined by flow cytometry in whole blood with and without in vitro heat shock. Significant differences were observed in the percentage of several white cell subsets that expressed hsp70. CD4 and CD8 lymphocytes expressed significantly more hsp70 in both males and females after supplementation but in natural killer cells and B lymphocytes, expression of hsp70 were only significantly increased in the male participant cohort. These results indicate that Echinacea may play a role in activating the immune system when the body encounters a challenge such as a virus.
Publication Type: Conference Publication
Conference Name: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September, 2010
Conference Details: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Berlin, Germany, 29th August - 2nd September, 2010
Source of Publication: Planta Medica: Journal of Medicinal Plant and Natural Product Research, v.76, p. 1354-1354
Publisher: Georg Thieme Verlag
Place of Publication: Germany
ISSN: 0032-0943
Field of Research (FOR): 110499 Complementary and Alternative Medicine not elsewhere classified
110399 Clinical Sciences not elsewhere classified
110704 Cellular Immunology
Socio-Economic Outcome Codes: 920412 Preventive Medicine
920108 Immune System and Allergy
HERDC Category Description: E3 Extract of Scholarly Conference Publication
Series Name: Planta Medica
Series Number : 76
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