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Title: Functional genomics of estimated breeding value for eye muscle depth in sheep
Contributor(s): Kogelman, L J A (author); Watson-Haigh, N S (author); Kadarmideen, H N (author); Kijas, J W (author); Vuocolo, T (author); Byrne, K (author); Oddy, Hutton  (author)orcid ; Gardner, Graham E (author); Gondro, Cedric  (author)orcid ; Tellam, R L (author)
Publication Date: 2011
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Abstract: A weighted gene co-expression network analysis (WGCN) and a differential network analysis were applied to microarray gene expression data for skeletal muscle samples from progeny of 6 Poll Dorset sires characterised as having high or low estimated breeding values (EBVs) for Eye Muscle Depth (EMD). There was strong genetic architecture to the gene expression data. Gene network analyses identified expression modules that were enriched for several biological themes including protein catabolism, ribosome function, mRNA processing, mitochondria and muscle structural proteins. These biological pathways likely contribute to the genetics of enhanced muscling in sheep.
Publication Type: Conference Publication
Conference Details: AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics, Perth, Australia, 19th - 21st July, 2011
Source of Publication: Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.19, p. 462-465
Publisher: Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of Publication: Armidale, Australia
ISSN: 1328-3227
Fields of Research (FoR) 2008: 070201 Animal Breeding
Socio-Economic Objective (SEO) 2008: 830310 Sheep - Meat
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
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Appears in Collections:Conference Publication

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