Functional genomics of estimated breeding value for eye muscle depth in sheep

Title
Functional genomics of estimated breeding value for eye muscle depth in sheep
Publication Date
2011
Author(s)
Kogelman, L J A
Watson-Haigh, N S
Kadarmideen, H N
Kijas, J W
Vuocolo, T
Byrne, K
Oddy, Hutton
( author )
OrcID: https://orcid.org/0000-0003-1783-1049
Email: hoddy2@une.edu.au
UNE Id une-id:hoddy2
Gardner, Graham E
Gondro, Cedric
( author )
OrcID: https://orcid.org/0000-0003-0666-656X
Email: cgondro2@une.edu.au
UNE Id une-id:cgondro2
Tellam, R L
Editor
Editor(s): William Pattie
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of publication
Armidale, Australia
UNE publication id
une:10278
Abstract
A weighted gene co-expression network analysis (WGCN) and a differential network analysis were applied to microarray gene expression data for skeletal muscle samples from progeny of 6 Poll Dorset sires characterised as having high or low estimated breeding values (EBVs) for Eye Muscle Depth (EMD). There was strong genetic architecture to the gene expression data. Gene network analyses identified expression modules that were enriched for several biological themes including protein catabolism, ribosome function, mRNA processing, mitochondria and muscle structural proteins. These biological pathways likely contribute to the genetics of enhanced muscling in sheep.
Link
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.19, p. 462-465
ISSN
1328-3227
ISBN
9780646559155
Start page
462
End page
465

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