Functional genomics of estimated breeding value for eye muscle depth in sheep

Author(s)
Kogelman, L J A
Watson-Haigh, N S
Kadarmideen, H N
Kijas, J W
Vuocolo, T
Byrne, K
Oddy, Hutton
Gardner, Graham E
Gondro, Cedric
Tellam, R L
Publication Date
2011
Abstract
A weighted gene co-expression network analysis (WGCN) and a differential network analysis were applied to microarray gene expression data for skeletal muscle samples from progeny of 6 Poll Dorset sires characterised as having high or low estimated breeding values (EBVs) for Eye Muscle Depth (EMD). There was strong genetic architecture to the gene expression data. Gene network analyses identified expression modules that were enriched for several biological themes including protein catabolism, ribosome function, mRNA processing, mitochondria and muscle structural proteins. These biological pathways likely contribute to the genetics of enhanced muscling in sheep.
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.19, p. 462-465
ISBN
9780646559155
ISSN
1328-3227
Link
Language
en
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Title
Functional genomics of estimated breeding value for eye muscle depth in sheep
Type of document
Conference Publication
Entity Type
Publication

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