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Title: Stabilization of Profilin I and II by Poly-L-Proline
Contributor(s): Krishnan, Kannan (author); Moens, Pierre  (author)orcid 
Publication Date: 2008
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Abstract: Profilins are small, 14- to 17-kDa proteins found in Plants, yeast, fungi, protozoa, mouse, human and certain viruses. Originally, profilin was identified to be involved in actin polymerization and its role established as a key regulator of F-actin dynamics. Apart from actin sequestering and polymerization, profilin plays several roles and has multiple binding partners. In Human, there are at least four isoforms of profilin, among them profilin I is expressed in all tissues, whereas other isoforms are tissue specific. Profilin II is brain specific and shown to be required for the neuronal development. In neuronal cells profilin II was shown to interact with ligands involved in signal transduction, membrane trafficking and vesicle recycling such as ROCK2, synapsins, POP-130/CyFIPI and dynamin 1. Profilins bind poly-L-proline (PLP) rich sequences and many proteins containing proline-rich stretches have been identified as potential ligands. ... The influence of PLP in profilin's structure and stability has not been investigated. Using fluorescence and Circular Dichroism we show that PLP extrinsically stabilizes Profilin in chemical denaturation experiments.
Publication Type: Conference Publication
Conference Name: ASB 2008: 32nd Annual Meeting of the Australian Society for Biophysics, Canberra, Australia, 28th September - 1st October, 2008
Conference Details: ASB 2008: 32nd Annual Meeting of the Australian Society for Biophysics, Canberra, Australia, 28th September - 1st October, 2008
Source of Publication: 32nd Annual Meeting of the Australian Society for Biophysics Programme, p. 26-26
Publisher: Australian Society for Biophysics
Place of Publication: Australia
Field of Research (FOR): 029901 Biological Physics
060112 Structural Biology (incl Macromolecular Modelling)
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
HERDC Category Description: E3 Extract of Scholarly Conference Publication
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