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<mods:titleInfo>
<mods:title>Novel Two-Stage Analytic Approach in Extraction of Strong Herb-Herb Interactions in TCM Clinical Treatment of Insomnia</mods:title>
</mods:titleInfo>
<mods:name type="personal">
<mods:namePart type="family">Zhou</mods:namePart>
<mods:namePart type="given">Xuezhong</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Poon</mods:namePart>
<mods:namePart type="given">Josiah</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
<mods:description>josiah@it.usyd.edu.au</mods:description>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Kwan</mods:namePart>
<mods:namePart type="given">Paul H</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
<mods:affiliation>Computer Science</mods:affiliation>
<mods:description>wkwan2@une.edu.au</mods:description>
<mods:description>une-id:wkwan2</mods:description>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Zhang</mods:namePart>
<mods:namePart type="given">Runshun</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Wang</mods:namePart>
<mods:namePart type="given">Yinhui</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Poon</mods:namePart>
<mods:namePart type="given">Simon</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Liu</mods:namePart>
<mods:namePart type="given">Baoyan</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
</mods:name>
<mods:name type="personal">
<mods:namePart type="family">Sze</mods:namePart>
<mods:namePart type="given">Daniel</mods:namePart>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
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<mods:abstract>In this paper, we aim to investigate strong herb-herb interactions in TCM for effective treatment of insomnia. Given that extraction of herb interactions is quite similar to gene epistasis study due to non-linear interactions among their study factors, we propose to apply Multifactor Dimensionality Reduction (MDR) that has shown useful in discovering hidden interaction patterns in biomedical domains. However, MDR suffers from high computational overhead incurred in its exhaustive enumeration of factors combinations in its processing. To address this drawback, we introduce a two-stage analytical approach which first uses hierarchical core sub-network analysis to pre-select the subset of herbs that have high probability in participating in herb-herb interactions, which is followed by applying MDR to detect strong attribute interactions in the pre-selected subset. Experimental evaluation confirms that this approach is able to detect effective high order herb-herb interaction models in high dimensional TCM insomnia dataset that also has high predictive accuracies. </mods:abstract>
<mods:language>
<mods:languageTerm type="code" authority="rfc4646">en</mods:languageTerm>
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<mods:note type="DEST category">B1</mods:note>
<mods:classification authority="for2008">080109 Pattern Recognition and Data Mining</mods:classification>
<mods:subject>
<mods:topic>Pattern Recognition and Data Mining</mods:topic>
</mods:subject>
<mods:classification authority="for2008">110404 Traditional Chinese Medicine and Treatments</mods:classification>
<mods:subject>
<mods:topic>Traditional Chinese Medicine and Treatments</mods:topic>
</mods:subject>
<mods:classification authority="for2008">080301 Bioinformatics Software</mods:classification>
<mods:subject>
<mods:topic>Bioinformatics Software</mods:topic>
</mods:subject>
<mods:classification authority="seo2008">920203 Diagnostic Methods</mods:classification>
<mods:classification authority="seo2008">890299 Computer Software and Services not elsewhere classified</mods:classification>
<mods:genre authority="local">book chapter</mods:genre>
<mods:relatedItem type="host">
<mods:titleInfo>
<mods:title>Medical Biometrics: Proceedings of the Second International Conference, ICMB 2010</mods:title>
</mods:titleInfo>
<mods:note type="statement of responsibility">Editor(s): David Zhang and Milan Sonka</mods:note>
<mods:originInfo>
<mods:place>
<mods:placeTerm type="text">Berlin, Germany</mods:placeTerm>
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<mods:publisher>Springer Verlag</mods:publisher>
<mods:dateIssued>2010</mods:dateIssued>
<mods:edition>1</mods:edition>
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<mods:identifier type="isbn">9783642139222</mods:identifier>
<mods:identifier type="isbn">3642139221</mods:identifier>
<mods:identifier type="doi">10.1007/978-3-642-13923-9</mods:identifier>
<mods:part>
<mods:extent unit="page">
<mods:start>258</mods:start>
<mods:end>267</mods:end>
</mods:extent>
<mods:detail type="total chapters">
<mods:number>44</mods:number>
</mods:detail>
</mods:part>
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<mods:relatedItem type="series">
<mods:titleInfo>
<mods:title>Lecture Notes in Computer Science</mods:title>
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<mods:part>
<mods:detail>
<mods:number>6165</mods:number>
</mods:detail>
</mods:part>
<mods:identifier type="issn">0302-9743</mods:identifier>
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<mods:recordInfo>
<mods:recordContentSource>University of New England</mods:recordContentSource>
<mods:recordIdentifier>une-20110324-13458</mods:recordIdentifier>
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