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The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers |
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10.1016/j.tet.2009.02.018 |
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| Abstract |
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The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-α-d-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell maturation was measured, however, no significant trends were observed. |
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Tetrahedron, 65(15), p. 2939-2950 |
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