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Bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep |
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Editor(s): Inma Estevez, Xavier Manteca, Raul H Marin, Xavier Averos |
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Wageningen Academic Publishers |
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The pain from routine husbandry practices performed on sheep can last several days and sheep often don't receive therapeutic interventions to provide pain relief. Attractive candidates for long-acting pain relief are non-steroidal anti-inflammatory drugs (NSAIDs). If NSAIDs can be shown to alleviate pain and inflammation when administered orally in sheep, they could be incorporated in feed, providing producers with a practical method to provide long-term pain relief in sheep. The aim of this research was to test the bioavailability and efficacy of carprofen, ketoprofen and flunixin administered orally using a lameness model (turpentine (0.1 ml) injected into one forelimb) developed to enable objective quantitative assessment of the analgesic, antipyretic and anti-inflammatory actions of NSAIDs in sheep. |
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Moving on: Proceedings of the 48th Congress of the International Society for Applied Ethology (ISAE 2014), p. 220-220 |
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