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Altered lymphocyte heat shock protein 70 expression in patients with HIV disease |
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Lippincott Williams & Wilkins |
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| Abstract |
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Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited. |
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AIDS, 17(13), p. 1985-1988 |
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