Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Author(s)
Agnew, L
Kelly, M
Howard, J
Jeganathan, S
Batterham, M
Ffrench, R
Gold, J
Watson, K
Publication Date
2003
Abstract
Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.
Citation
AIDS, 17(13), p. 1985-1988
ISSN
1473-5571
0269-9370
Link
https://hdl.handle.net/1959.11/844
Publisher
Lippincott Williams & Wilkins
Title
Altered lymphocyte heat shock protein 70 expression in patients with HIV disease
Type of document
Journal Article
Entity Type
Publication

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