Climate change poses a threat to crop production and livelihoods of rural farming communities in Kenya, a majority of whom are mainly dependent on rain-fed agriculture. The purpose of this study was to examine farm-level adaptation responses towards climate change and their influencing factors, using a case study of western Kenya. Structured questionnaire was administered to 210 farmers in selected locations in the region where households farm maize as the main crop. Logistic and multiple linear regression models were used to ascertain the factors that influence farmers' adaptation practices. The results indicate that farmers perceived climate change as being responsible for the reduction in crop yield and production, crop failure and increase of fallow farms. The major adaptation strategies undertaken by the farmers included change in planting dates by either planting early or late during a season, diversification of crops, growing early maturing cultivars, use of drought-tolerant varieties and timely planting. The key determinants of adaptation strategies by the farmers included farm size, income and extension training. Understanding farmers' responses to climate change in rain-fed crop production systems could assist in planning adaptation strategies towards sustainable crop production.