Hospitalisation costs associated with heart failure with preserved ejection fraction (HFpEF): a systematic review

Title
Hospitalisation costs associated with heart failure with preserved ejection fraction (HFpEF): a systematic review
Publication Date
2022-03
Author(s)
Clark, Hannah
Rana, Rezwanul
Gow, Jeff
Pearson, Melissa
( author )
OrcID: https://orcid.org/0000-0003-2639-2615
Email: mpears28@une.edu.au
UNE Id une-id:mpears28
van der Touw, Tom
Smart, Neil
( author )
OrcID: https://orcid.org/0000-0002-8290-6409
Email: nsmart2@une.edu.au
UNE Id une-id:nsmart2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Springer New York LLC
Place of publication
United States of America
DOI
10.1007/s10741-021-10097-7
UNE publication id
une:1959.11/31891
Abstract

Heart failure with preserved ejection fraction (HFpEF) is problematic to treat, with guidelines for HFpEF management concentrated on treating prevalent comorbidities. The aim of this study is to conduct a systematic review of the economic burden of hospitalisation for HFpEF. We conducted a systematic literature search from 2001, when HFpEF was first identified as an isolated diagnosis, up to July 1, 2020. Databases searched include PubMed, Medline, EMBASE, EBSCO, National Health Service Economic Evaluation and the National Bureau of Economic Research. The primary outcome measure was hospitalisation costs related to HFpEF. A comprehensive search of the literature produced a total of 243 possible studies. A total of nine studies, six from the U.S., met inclusion criteria and were included in this review. All results are presented in United States Dollars (US$) for the financial year 2019. Costs of index (the first) hospitalisation ranged from mean US$8340 up to US$11,366 per admission and increased up to US$31,493 for those with comorbidities. Two studies reported 1-year costs, and these were US$27,174 and US$26,343, respectively. Hospitalisation accounts for approximately 80% of total costs of HFpEF treatment. The results of this systematic review reveal that published costs of HFpEF hospitalisation are limited to nine studies from a comprehensive database search. The costs of an initial HF hospitalisation are significant, and these costs increase when a person with HFpEF presents with comorbidities or other complications.

Link
Citation
Heart Failure Reviews, 27(2), p. 559-572
ISSN
1573-7322
1382-4147
Pubmed ID
33765251
Start page
559
End page
572

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