Si, Jingfang

Dai, Dongmei

Gorkhali, Neena Amatya

Wang, Mingshan

Wang, Sheng

Sapkota, Saroj

Kadel, Ram Chandra

Sadaula, Amir

Dhakal, Aashish

Faruque, Md Omar

Omar, Abdullah Ibne

Sari, Eka Meutia

Ashari, Hidayat

Andi Dagong, Muhammad Ihsan

Yindee, Marnoch

Rushdi, Hossam E

Elregalaty, Hussein

Amin, Ahmed

Radwan, Mohamed A

Pham, Lan Doan

Hulugalla, W M M P

Pradeepa Silva, G L L

Zheng, Wei

Mansoor, Shahid

Basil Ali, Muhammad

Vahidi, Farhad

Al‐Bayatti, Sahar Ahmed

Pauciullo, Alfredo

Lenstra, Johannes A

Barker, J Stuart F

Fang, Lingzhao

Wu, Dong‐Dong

Han, Jianlin

Zhang, Yi

2025-01-27

<p>To identify the genetic determinants of domestication and productivity of Asian water buffaloes (<i>Bubalus bubalis</i>), 470 genomes of domesticated river and swamp buffaloes along with their putative ancestors, the wild water buffaloes (<i>Bubalus arnee</i>) are sequenced and integrated. The swamp buffaloes inherit the morphology of the wild buffaloes. In contrast, most river buffaloes are unique in their morphology, but their genomes cluster with the wild buffaloes. The levels of genomic diversity in Italian river and Indonesian swamp buffaloes decrease at opposite extremes of their distribution range. Purifying selection prevented the accumulation of harmful loss-of-function variants in the Indonesian buffaloes. Genes that evolved rapidly (e.g., <i>GKAP1</i>) following differential selections in the river and swamp buffaloes are involved in their reproduction. Genes related to milk production (e.g., <i>CSN2</i>) and coat color (e.g., <i>MC1R</i>) underwent strong selections in the dairy river buffaloes via soft and hard selective sweeps, respectively. The selective sweeps and single-cell RNA-seq data revealed the luminal cells as the key cell type in response to artificial selection for milk production of the dairy buffaloes. These findings show how artificial selection has been driving the evolutionary divergence and genetic differentiation in morphology and productivity of Asian water buffaloes.</p>

Advanced Science, 12(4), p. 1-13

2198-3844

https://hdl.handle.net/1959.11/70427

en

Wiley-VCH Verlag GmbH & Co KGaA

Attribution 4.0 International

Complete Genomic Landscape Reveals Hidden Evolutionary History and Selection Signature in Asian Water Buffaloes (Bubalus bubalis)

Journal Article

Publication