Sun, Liang; Pitto-Barry, Anais; Kirby, Nigel; Schiller, Tara; Sanchez, Ana M; Dyson, M Adam; Sloan, Jeremy; Wilson, Neil R; O'Reilly, Rachel K; Dove, Andrew P

Author(s)

Sun, Liang

Pitto-Barry, Anais

Kirby, Nigel

Schiller, Tara

Sanchez, Ana M

Dyson, M Adam

Sloan, Jeremy

Wilson, Neil R

O'Reilly, Rachel K

Dove, Andrew P

Publication Date

2014

Abstract

Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H₂O mixtures or in pure water at 65°C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.

Citation

Nature Communications, v.5, p. 1-9

ISSN

2041-1723

Link

https://hdl.handle.net/1959.11/17808

Publisher

Nature Publishing Group

Title

Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

Type of document

Journal Article

Entity Type

Publication

Author(s)	Sun, Liang Pitto-Barry, Anais Kirby, Nigel Schiller, Tara Sanchez, Ana M Dyson, M Adam Sloan, Jeremy Wilson, Neil R O'Reilly, Rachel K Dove, Andrew P
Publication Date	2014
Abstract	Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H₂O mixtures or in pure water at 65°C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.
Citation	Nature Communications, v.5, p. 1-9
ISSN	2041-1723
Link	https://hdl.handle.net/1959.11/17808
Publisher	Nature Publishing Group
Title	Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation
Type of document	Journal Article
Entity Type	Publication

Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

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