Help-seeking stigma is a major barrier to the utilisation of mental health services. This is especially so for young rural Australians who, despite being particularly susceptible to the onset of mental illness, have the lowest tendency to seek professional help compared to the broader Australian population. While some interventions strive to enhance help-seeking, few studies have examined the efficacy of web-based interventions for improving attitudes towards mental health help-seeking behaviour. This thesis aims to examine the efficacy of these interventions within a young rural population, as rural young people have not been the focus of previous intervention research in this area. Five studies were undertaken to address the aims, commencing with Study One, a systematic review that evaluated the impact web-based anti-stigma intervention strategies have on modifying mental health help-seeking stigma intentions and behaviours in young people (14–25 years). These interventions were found to have strong practical implications that highlighted the need for further exploration guided by theory and improved methodology. Study Two expands this existing evidence base to add to the current body of research through the piloting of alternative early intervention strategies: Internet-Based Cognitive Behavioural Therapy (ICBT) and Cognitive Bias Modification for Help-Seeking (CBM-HS) for decreasing mental health stigma and increasing young rural Australians’ intentions to access services. Contrary to predictions, findings were limited regarding outcomes of stigma and intentions. Yet, data trends indicated greater reductions in self-stigma levels for the CBM-HS condition compared to the ICBT and control, suggesting improved implementation may yield stronger effects. Studies Three and Four used qualitative feedback to aid in understanding young Australians’ current mental health perceptions and in assessing the acceptability of intervention strategies for adapting future mental health interventions to be both inclusive and effective in their dissemination. Predicated on these findings, Study Five conducted a superiority analysis on CBM-HS and ICBT, with a control condition across three time points (spanning 6 weeks) for the modification of help-seeking stigma in young, rural Australians to increase intentions to access mental health services within Australia. As predicted, the results provided support for CBM-HS interventions as effective in decreasing mental health help-seeking self-stigma across the three time points compared to the ICBT condition and control. CBM-HS also showed positive trends in decreasing negative normative beliefs, attitudes, and perceived barriers to help-seeking. A significant increase in mean mental health literacy (MHL) scores and intentions to seek help from informal sources (partner, parents, friends, and phone) were found between time points with no discernible differences across conditions. These outcomes offer some practical implications for the effective delivery of online anti-stigma interventions targeting young rural Australians, including improved engagement through the age-stratified tailoring of materials and incorporation of visual and auditory stimulation. To overcome structural inequalities and combat the embedded stigma in young rural peoples’ mental health help-seeking, technology-based alternatives that utilise mechanisms of change (i.e., CBM-HS) are needed to guide preventative mental health interventions. This can potentially bridge the gap between intentions and actual help-seeking behaviours and allow for enhanced timely treatment uptake and the promotion of improved clinical outcomes for young rural Australians.