Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions

2021-04

Deng, Liting

Gupta, Vivek K

Wu, Yunqi

Pushpitha, Kanishka

Chitranshi, Nitin

Gupta, Veer B

Fitzhenry, Matthew J

Zabet Moghaddam, Masoud

Karl, Tim

Hosseini Salekdeh, Ghasem

Graham, Stuart L

Haynes, Paul A

Mirzaei, Mehdi

Journal Article

en

Publication

Wiley-VCH Verlag GmbH & Co KGaA

Germany

10.1002/pmic.202000213

une:1959.11/71705

Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.

link

Proteomics, 21(7-8), p. 1-7

1615-9861

1615-9853

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