Comparing a genetic and a psychological factor as correlates of anxiety, depression, and chronic stress in men with prostate cancer

Title
Comparing a genetic and a psychological factor as correlates of anxiety, depression, and chronic stress in men with prostate cancer
Publication Date
2018-09
Author(s)
Sharpley, Christopher F
( author )
OrcID: https://orcid.org/0000-0001-7922-4848
Email: csharpl3@une.edu.au
UNE Id une-id:csharpl3
Christie, David R H
Bitsika, Vicki
( author )
OrcID: https://orcid.org/0000-0003-2518-6684
Email: vbitsik2@une.edu.au
UNE Id une-id:vbitsik2
Andronicos, Nicholas M
( author )
OrcID: https://orcid.org/0000-0001-5881-2296
Email: nandroni@une.edu.au
UNE Id une-id:nandroni
Agnew, Linda L
( author )
OrcID: https://orcid.org/0000-0002-2803-0995
Email: lagnew2@une.edu.au
UNE Id une-id:lagnew2
Richards, Timothy M
McMillan, Mary E
( author )
OrcID: https://orcid.org/0000-0002-2336-3985
Email: mrookle2@une.edu.au
UNE Id une-id:mrookle2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Springer
Place of publication
Germany
DOI
10.1007/s00520-018-4183-4
UNE publication id
une:1959.11/26656
Abstract
Purpose: Some prostate cancer (PCa) patients become clinically anxious or depressed after diagnosis and treatment. Some also show the physiological signs of chronic stress. However, there are currently no data describing how these particular patients might be identified at intake. This study tested the individual and combined predictive power of a psychological factor and a genetic factor as potential predictors of anxiety, depression, and chronic stress in a sample of PCa patients. Methods: Ninety-five PCa patients completed psychological inventories for anxiety, depression, and psychological resilience (PR) and also gave a saliva sample for cortisol and a mouthwash sample for genetic testing for the presence of the BDNF Val66Met polymorphism. Results: High PR patients had significantly lower anxiety and depression than low PR patients, but showed no significant differences in their salivary cortisol. Carriers of the Met allele of the BDNF Val66Met polymorphism had significantly higher salivary cortisol concentrations than patients who did not carry this allele. Conclusions: Each of these two factors may provide valuable information regarding the vulnerability of PCa patients to anxiety, depression, or chronic stress. Suggestions are made for their inclusion in clinical settings.
Link
Citation
Supportive Care in Cancer, 26(9), p. 3195-3200
ISSN
1433-7339
0941-4355
Start page
3195
End page
3200

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