Accounting for trait-specific genomic and residual polygenic covariances in multivariate single-step genomic evaluation

Title
Accounting for trait-specific genomic and residual polygenic covariances in multivariate single-step genomic evaluation
Publication Date
2023-02-09
Author(s)
Meyer, K
( author )
OrcID: https://orcid.org/0000-0003-2663-9059
Email: kmeyer@une.edu.au
UNE Id une-id:kmeyer
Editor
Editor(s): R F Veerkamp and Y De Hass
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
Wageningen Academic Publishers
Place of publication
Wageningen, The Netherlands
DOI
10.3920/978-90-8686-940-4_361
UNE publication id
une:1959.11/57543
Abstract

For multivariate, single-step genomic best linear unbiased prediction analyses fitting a breeding value model, it is often assumed that the proportions of total genetic variance accounted for by genomic markers and residual polygenic effects are the same for all traits. Different covariance matrices for the two types of genetic effects are readily taken into account by fitting them separately. However, this can lead to slow convergence rates in iterative solution schemes. We propose an alternative computing strategy which – exploiting a canonical transformation – allows for trait-specific covariances whilst directly fitting total genetic effects only. Its effects on convergence rates and gains in accuracy and bias of genomic evaluation compared to analyses assuming proportionality of covariance matrices are examined using a small simulation study. Results show comparatively little improvement in accuracies but worthwhile reductions in overdispersion of predicted genetic merits for genotyped individuals without phenotypes.

Link
Citation
Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, v.12, p. 1510-1514
ISBN
9789086869404
Start page
1510
End page
1514
Rights
Attribution 4.0 International

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administrative/Proceedingsof12thWorldCongressoGeneticsAppliedt LivestockProduction2022ConferenceProgram.pdf 7109.32 KB application/pdf Conference Program View document
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