Novel endoperoxides: Synthesis and activity against 'Candida' species

Author(s)
Macreadie, Peter
Avery, Thomas D
Greatrex, Ben
Taylor, Dennis K
Macreadie, Ian G
Publication Date
2006
Abstract
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic 'Candida' species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against 'Candida' growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
Citation
Bioorganic & Medicinal Chemistry Letters, 16(4), p. 920-922
ISSN
1464-3405
0960-894X
Link
Language
en
Publisher
Pergamon Press
Title
Novel endoperoxides: Synthesis and activity against 'Candida' species
Type of document
Journal Article
Entity Type
Publication

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