Jiang, Yu; Xie, Min; Stanton, Jo-Ann; Brauning, Rudiger; Barris, Wesley C; Hourlier, Thibaut; Aken, Bronwen L; Searle, Stephen M J; Adelson, David L; Bian, Chao; Cam, Graham R; Chen, Yulin; Chen, Wenbin; Cheng, Shifeng; DeSilva, Udaya; Dixen, Karen; Dong, Yang; Fan, Guangyi; Franklin, Ian R; Fu, Shaoyin; Fuentes-Utrilla, Pablo; Guan, Rui; Highland, Margaret A; Talbot, Richard; Holder, Michael E; Huang, Guodong; Ingham, Aaron B; Jhangiani, Shalini N; Kalra, Divya; Kovar, Christie L; Lee, Sandra; Liu, Weiqing; Liu, Xin; Lu, Changxin; Maddox, Jillian F; Lv, Tian; Mathew, Tittu; McWilliam, Sean; Menzies, Moira; Pan, Shengkai; Robelin, David; Servin, Bertrand; Townley, David; Wang, Wenliang; Wei, Bin; Faraut, Thomas; White, Stephen N; Yang, Xinhua; Ye, Chen; Yue, Yaojing; Zeng, Peng; Zhou, Qing; Hansen, Jacob B; Kristiansen, Karsten; Gibbs, Richard A; Flicek, Paul; Wu, Chunhua; Warkup, Christopher C; Jones, Huw E; Oddy, Hutton; Nicholas, Frank W; McEwan, John C; Kijas, James W; Wang, Jun; Worley, Kim C; Archibald, Alan L; Cockett, Noelle; Muzny, Donna M; Xu, Xun; Wang, Wen; Dalrymple, Brian P; Li, Yuxiang; Zhang, Wenguang

Author(s)

Jiang, Yu

Xie, Min

Stanton, Jo-Ann

Brauning, Rudiger

Barris, Wesley C

Hourlier, Thibaut

Aken, Bronwen L

Searle, Stephen M J

Adelson, David L

Bian, Chao

Cam, Graham R

Chen, Yulin

Chen, Wenbin

Cheng, Shifeng

DeSilva, Udaya

Dixen, Karen

Dong, Yang

Fan, Guangyi

Franklin, Ian R

Fu, Shaoyin

Fuentes-Utrilla, Pablo

Guan, Rui

Highland, Margaret A

Talbot, Richard

Holder, Michael E

Huang, Guodong

Ingham, Aaron B

Jhangiani, Shalini N

Kalra, Divya

Kovar, Christie L

Lee, Sandra

Liu, Weiqing

Liu, Xin

Lu, Changxin

Maddox, Jillian F

Lv, Tian

Mathew, Tittu

McWilliam, Sean

Menzies, Moira

Pan, Shengkai

Robelin, David

Servin, Bertrand

Townley, David

Wang, Wenliang

Wei, Bin

Faraut, Thomas

White, Stephen N

Yang, Xinhua

Ye, Chen

Yue, Yaojing

Zeng, Peng

Zhou, Qing

Hansen, Jacob B

Kristiansen, Karsten

Gibbs, Richard A

Flicek, Paul

Wu, Chunhua

Warkup, Christopher C

Jones, Huw E

Oddy, Hutton

Nicholas, Frank W

McEwan, John C

Kijas, James W

Wang, Jun

Worley, Kim C

Archibald, Alan L

Cockett, Noelle

Muzny, Donna M

Xu, Xun

Wang, Wen

Dalrymple, Brian P

Li, Yuxiang

Zhang, Wenguang

Publication Date

2014

Abstract

Sheep ('Ovis aries') are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

Citation

Science, 344(6188), p. 1168-1173

ISSN

1095-9203

0036-8075

Link

https://hdl.handle.net/1959.11/17813

Publisher

American Association for the Advancement of Science (AAAS)

Title

The sheep genome illuminates biology of the rumen and lipid metabolism

Type of document

Journal Article

Entity Type

Publication

Author(s)	Jiang, Yu Xie, Min Stanton, Jo-Ann Brauning, Rudiger Barris, Wesley C Hourlier, Thibaut Aken, Bronwen L Searle, Stephen M J Adelson, David L Bian, Chao Cam, Graham R Chen, Yulin Chen, Wenbin Cheng, Shifeng DeSilva, Udaya Dixen, Karen Dong, Yang Fan, Guangyi Franklin, Ian R Fu, Shaoyin Fuentes-Utrilla, Pablo Guan, Rui Highland, Margaret A Talbot, Richard Holder, Michael E Huang, Guodong Ingham, Aaron B Jhangiani, Shalini N Kalra, Divya Kovar, Christie L Lee, Sandra Liu, Weiqing Liu, Xin Lu, Changxin Maddox, Jillian F Lv, Tian Mathew, Tittu McWilliam, Sean Menzies, Moira Pan, Shengkai Robelin, David Servin, Bertrand Townley, David Wang, Wenliang Wei, Bin Faraut, Thomas White, Stephen N Yang, Xinhua Ye, Chen Yue, Yaojing Zeng, Peng Zhou, Qing Hansen, Jacob B Kristiansen, Karsten Gibbs, Richard A Flicek, Paul Wu, Chunhua Warkup, Christopher C Jones, Huw E Oddy, Hutton Nicholas, Frank W McEwan, John C Kijas, James W Wang, Jun Worley, Kim C Archibald, Alan L Cockett, Noelle Muzny, Donna M Xu, Xun Wang, Wen Dalrymple, Brian P Li, Yuxiang Zhang, Wenguang
Publication Date	2014
Abstract	Sheep ('Ovis aries') are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
Citation	Science, 344(6188), p. 1168-1173
ISSN	1095-9203 0036-8075
Link	https://hdl.handle.net/1959.11/17813
Publisher	American Association for the Advancement of Science (AAAS)
Title	The sheep genome illuminates biology of the rumen and lipid metabolism
Type of document	Journal Article
Entity Type	Publication

The sheep genome illuminates biology of the rumen and lipid metabolism

Files: